The Problem

About Short Bowel Syndrome

Short Bowel Syndrome (SBS) is a devastating condition where the small intestine is too short to absorb sufficient nutrients to sustain a patient. It results from the surgical removal of a large portion of the small intestine due to a congenital or acquired defect.

No restorative solution today

Total Parenteral Nutrition
(TPN)

  • Lifelong IV feeding
  • Frequent hospitalizations for
    venous catheter infections
  • Causes toxicity often leading
    to end-stage liver disease

Drug therapy
(Teduglutide injections)

  • Daily injections
  • Minimal improvement in
    absorption (max 20%)
  • TPN/IV nutrition still required

Surgery and intestinal transplantation

  • May not increase
    nutrient absorption
  • May require lifelong
    immunosuppression drugs
  • High risk of infection,
    rejection, death

Impact

Patients suffer from
malabsorption and malnutrition

0% of neonatal patients
die before age 3
0M patient cost
over 5 years
0B+/year total cost to
healthcare system

Our Solution

The Eclipse XL1 therapy is designed to grow 2-3x longer, healthy intestine within 2-3 weeks using an entirely mechanical, repeatable approach. The new tissue has been shown to absorb nutrients and function the same as, or better than, healthy intestinal tissue.

See how Eclipse XL1 therapy works

In many areas of medicine such as bone lengthening and skin expansion, it has been proven that appropriately applied forces can cause the genesis of new functional tissue (mechanotransduction).

The Eclipse XL1’s mechanism of action has been rigorously studied in extensive pre-clinical trials at institutions such as UCLA and Stanford over the last 10 years, resulting in 20+ peer reviewed publications.

Future studies will be conducted to determine if the therapy may enable patients to eliminate IV nutrition and enjoy real food and an improved quality of life.

Our Team

The Eclipse team encompasses:

  • World leaders in SBS
  • Top pediatric centers in the U.S.
  • Proven track record of successful medtech M&A
  • Optimal blend of engineering, science and medical experience

Co-Founders

Andre Bessette
CEO, Co-Founder

Vantage Surgical,
SentreHeart,

PEAK Surgical,
ArthroCare

James Dunn, MD, PhD
Co-Founder

Chief of Pediatric Surgery,
Stanford University

Former Chief of
Pediatric Surgery, UCLA

Tom Krummel, MD
Co-Founder

Professor of Surgery,
Stanford University

Co-Director,
Stanford Biodesign Program

Medical Advisors

Michael Helmrath, MD

Pediatric Surgeon,
Cincinnati Children’s Hospital

Professor of Surgery,
Cincinnati School of Medicine

Mark Puder, MD

Professor of Surgery,
Harvard Medical School

Pediatric Surgeon,
Boston Children’s Hospital

James Wall, MD

Pediatric Surgeon,
Stanford University

Co-Director,
Stanford Biodesign Program

References

  1. Dubrovsky, G., Huynh, N., Thomas, A.L., Shekherdimian, S., Dunn, J.C.Y. Intestinal lengthening via multiple in-continuity springs. Journal of Pediatric Surgery 54: 39-43. 2019. PMID: 30361072.
  2. Dubrovsky, G., Huynh, N., Thomas, A.L., Shekherdimian, S., Dunn JC.Y. Double plication for spring-mediated in-continuity intestinal lengthening in a porcine model. Surgery 165(2):389-392, 2019. PMID 30217395.
  3. Huynh, N., Dubrovsky, G., Rouch, J.D., Scott, A., Chiang, E., Nguyen, T., Wu, B.M., Shekherdimian, S., Krummel, T.M., Dunn, J.C.Y. Three-dimensionally printed surface features to anchor endoluminal spring for distraction enterogenesis. PLoS One 13(7):e0200529, 2018. PMCID: PMC6042758.
  4. Huynh, N., Dubrovsky, G., Rouch, J.D., Scott, A., Stelzner, M., Shekherdimian, S., Dunn, J.C.Y. Feasibility and scalability of spring parameters in distraction enterogenesis in a murine model. Journal of Surgical Research 215:219-224, 2017. PMID: 28688651.
  5. Dubrovsky, G., Huynh, N., Thomas, A.L., Shekherdimian, S., Dunn, J.C.Y. Double plication for spring-mediated intestinal lengthening of a defunctionalized Roux limb. Journal of Pediatric Surgery 53(9):1806-1810, 2017. PMID: 29352575.
  6. Rouch, J.D., Huynh, N., Scott, A., Chiang, E., Wu, B.M., Shekherdimian, S., Dunn, J.C.Y. Scalability of an endoluminal spring for distraction enterogenesis. Journal of Pediatric Surgery 51(12):1988-1992, 2016. PMID: 27665493.
  7. Huynh, N., Rouch, J.D., Scott, A., Chiang, E., Wu, B.M., Shekherdimian, S., Dunn, J.C.Y. Spring mediated distraction enterogenesis in-continuity. Journal of Pediatric Surgery 51(12):1983-1987, 2016. PMID: 27692863.
  8. Rouch, J.D., Scott, A., Jabaji, Z.B., Chiang, E., Wu, B.M., Lee, S.L., Shekherdimian, S., Dunn, J.C.Y. Basic fibroblast growth factor eluting microspheres enhance distraction enterogenesis. Journal of Pediatric Surgery, pii: S0022-3468(16)00153-6. doi: 10.1016/j.jpedsurg.2016.02.065, 2016. PMID: 26995517.
  9. Scott, A., Rouch, J.D., Huynh, N., Chiang, E., Shekherdimian, S., Lee, S.L., Wu, B.M., Dunn, J.C.Y. Mechanical lengthening in multiple intestinal segments in-series. Journal of Pediatric Surgery, pii: S0022-3468(16)00146-9. doi: 10.1016/j.jpedsurg.2016.02.058, 2016. PMID: 27013424.
  10. Scott, A., Sullins, V.F., Steinberger, D., Rouch, J.D., Wagner, J.P., Chiang, El., Lee, S.L., Wu, B.M., Dunn, J.C.Y. Repeated mechanical lengthening of intestinal segments in a novel model. Journal of Pediatric Surgery 50(6):954-957, 2015. PMID: 25818320.
  11. Sullins, V.F., Scott, A., Wagner, J.P., Steinberger, D., Lee, S.L., Wu, B.M., Dunn, J.C.Y Intestinal lengthening in an innovative rodent surgical model. Journal of Pediatric Surgery 49(12):1791-1794, 2014. PMID: 25487485.
  12. Sullins, V.F., Scott, A., Wagner, J.P., Steinberger, D., Lee, S.L., Wu, B.M., Dunn, J.C.Y Intestinal lengthening in an innovative rodent surgical model. Journal of Pediatric Surgery 49(12):1791-1794, 2014. PMID: 25487485.
  13. Sullins, V.F., Scott, A., Wagner, J.P., Steinberger, D., Lee, S.L., Wu, B.M., Dunn, J.C.Y Intestinal lengthening in an innovative rodent surgical model. Journal of Pediatric Surgery 49(12):1791-1794, 2014. PMID: 25487485.
  14. Sullins, V.F., Scott, A., Wagner, J.P., Steinberger, D., Lee, S.L., Wu, B.M., Dunn, J.C.Y Intestinal lengthening in an innovative rodent surgical model. Journal of Pediatric Surgery 49(12):1791-1794, 2014. PMID: 25487485.
  15. Stark, R. and Dunn, J.C.Y. Mechanical enterogenesis – a review. Journal of Healthcare Engineering 3(2): 229–242, 2012.
  16. Stark, R. and Dunn, J.C.Y. Mechanical enterogenesis – a review. Journal of Healthcare Engineering 3(2): 229–242, 2012.
  17. Stark, R., Zupekan, T., Bondada, S., Dunn, J.C.Y. Restoration of mechanically lengthened jejunum into intestinal continuity in rats. Journal of Pediatric Surgery 46(12): 2321-2326, 2011.
  18. Shekherdimian, S., Panduranga, M.K., Carman, G.P., Dunn, J.C. The Feasibility of using an endoluminal device for intestinal lengthening. Journal of Pediatric Surgery, 45(8): 1575-1580, 2010.
  19. Shekherdimian, S., Scott, A., Chan, A., Dunn, J.C. Intestinal lengthening in rats after massive small intestinal resection. Surgery 146(2): 291-295, 2009.
  20. Dunn, J.C.Y., Lam, M.M., Lee, E. Increased expression of insulin-like growth factor in intestinal lengthening by mechanical force in rats. Journal of Pediatric Surgery 42(12): 2057-2061, 2007.
  21. Chang, P.C.Y., Mendoza, J. Park, J., Lam, M.M., Wu, B., Atkinson, J.B., Dunn, J.C.Y. Sustainability of mechanically lengthened bowel in rats. Journal of Pediatric Surgery 41: 2019-2022, 2006.
  22. Mendoza, J., Chang, C., Blalock, C.L., Atkinson, J.B., Wu, B.M., Dunn, J.C.Y. Contractile function of the mechanically lengthened intestine. Journal of Surgical Research 136: 8-12, 2006.
  23. Puapong, D.P., Wu, B.M., Lam, M.M., Atkinson, J.B., Dunn, J.C.Y. Distension enterogenesis: increasing the size and function of small intestine, Journal of Pediatric Surgery 41(4): 763-767, 2006.
  24. Park, J., Puapong, D.P., Wu, B.M., Atkinson, J.B., Dunn, J.C.Y. Enterogenesis by mechanical lengthening: morphology and function of the lengthened small intestine. Journal of Pediatric Surgery 39(12):1823-1827, 2004.

We welcome your interest and
questions about our therapy.

Contact Us

Eclipse Regenesis™
1490 O’Brien Drive, Suite C
Menlo Park, CA 94025

eclipse

The Eclipse XL 1 device is an investigational product and limited by Federal law to
investigational use. It is not currently available for commercial sale in the U.S. or
any other region.

Eclipse Regenesis and Eclipse XL1 are registered trademarks of Eclipse Regenesis, Inc.
© 2019 Eclipse Regenesis, Inc.